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N-Octyl pyrrolidone(NOP) is a highly efficient and selective solvent, which can be used in the recovery of organic raw materials, the refining of lubricating oils, and the solvent for polymers and polymerization reactions; It is also widely used in chemical synthesis reactions.
2-pyrrolidinon
Octanal
1-n-octyl-2-pyrrolidinone
| Conditions | Yield |
|---|---|
|
With
hydrogen; sodium sulfate;
palladium on activated charcoal;
In
ethyl acetate;
at 100 ℃;
for 4h;
under 30002.4 Torr;
|
93% |
|
With
hydrogen; sodium sulfate;
palladium on activated charcoal;
In
ethyl acetate;
at 100 ℃;
for 4h;
under 30002.4 Torr;
|
93% |
2-pyrrolidinon
1-bromo-octane
1-n-octyl-2-pyrrolidinone
| Conditions | Yield |
|---|---|
|
With
potassium tert-butylate;
In
dimethyl sulfoxide;
|
85% |
|
With
NaH;
In
toluene; Petroleum ether;
|
The CAS number of N-Octyl pyrrolidone is 2687-94-7.
More information of N-Octyl pyrrolidone 2687-94-7 are:
|
CAS Number |
2687-94-7 |
|
Density |
0.926 g/cm3 |
|
Melting Point |
-25 °C(lit.) |
|
Boiling Point |
303.1 °C at 760 mmHg |
|
Flash Point |
129 °C |
|
Vapor Pressure |
0.000948mmHg at 25°C |
|
Refractive Index |
n20/D 1.465(lit.) |
|
HS CODE |
29339900 |
|
PSA |
20.31000 |
|
LogP |
2.90720 |
|
Pka |
-0.42±0.20(Predicted) |
Synonyms for N-Octyl pyrrolidone 2687-94-7:1-Octyl-2-pyrrolidinone;1-Octyl-2-pyrrolidone;AgsolEx 8;Flexidone 100;ISP-LP 100;LP 100;N-Octyl-2-pyrrolidinone;N-Octylpyrrolidone;N-n-Octyl-2-pyrrolidone;N-n-Octyl-a-pyrrolidone;Surfadone LP 100;N-Octyl-2-pyrrolidone;N-Octylpyrrolidinone;N-Octylbutyrolactam;
The chemical formula of N-Octyl pyrrolidone is C12H23NO which containing 12 Carbon atoms,23 Hydrogen atoms,1 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of N-Octyl pyrrolidone is 197.321.
N-Octyl pyrrolidone (NOP), also known as 1-Octyl-2-pyrrolidone, is a colorless or slightly yellow clear liquid that serves as a highly efficient and selective solvent. It is recognized for its ability to enhance the transport of steroidal permeants across hairless mouse skin through a parallel pathway skin model, making it a valuable permeation enhancer in the pharmaceutical industry.
InChI:InChI=1/C12H23NO/c1-2-3-4-5-6-7-10-13-11-8-9-12(13)14/h2-11H2,1H3
Relevant articles related to N-Octyl pyrrolidone:
|
Article |
Source |
|
Tick repellents. II: N-substituted azacyclopentanones and azacyclopentenones |
Skinner,Rosentreter,Elward , p. 1354 - 1356 (1983) |
|
Reductive O- and N-alkylations. Alternative catalytic methods to nucleophilic substitution |
Fache, Fabienne,Bethmont, Valerie,Jacquot, Laurent,Lemaire, Marc , p. 231 - 238 (2007/10/03) |
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